Candidate gene studies are known to be pretty horrible (a vast, vast majority of them do not replicate), and the correct standard are GWASes. My understanding is that your proposed targets DEC2 and ADRB1 are both candidate gene studies, and neither of them show up in the GWAS Catalog (https://forum.effectivealtruism.org/posts/nSwaDrHunt3ohh9Et/cause-area-short-sleeper-genes?commentId=GCQf5qjG4LyEdEJov). Given that, I am quite skeptical of your specific gene targets. I am unfamiliar with the literature though and haven't read any of the references in your bibliography, and would change my mind if there has been any GWAS-based evidence in favor of DEC2 and ADRB1 recently (none showed up in the GWAS Catalog 2 years ago, according to the above EA forums). With that said, I'm very excited about the idea of sleep-reduction (and thank you for doing this work), and I'd be much more optimistic about this project if your gene targets were chosen via GWAS.